GeneMatch - Check if you and your donor are a healthy match - SellmerDiers
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Introducing GeneMatch

Check if you and your donor are a healthy match

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Why test your genes? 

We test our donors extensively to make sure that all accepted donors are healthy. But the donor is only half of the potential pregnancy and child. Your genes play a part too. This is why we offer an additional genetic test that screens your genes for 400+ conditions and compares them with your donor’s genes to ensure that you are a healthy match. 

Reduce your worries with a genetic screening 

Genetics is a complex piece of our biology and you may spend a lot of time worrying that your preferred donor carries certain genetic diseases that could be transferred to your child – or you may know that you yourself are a carrier of a disease. The fact of the matter is that our genes contain errors – or so-called mutations – which means that we are all carriers of genetic diseases. Even if we are not sick or otherwise affected by the disease, our mutations can cause disease in our children. In many cases, the biggest risk for a child inheriting a genetic disease is when the man and the woman have mutations in the same gene. 

To reduce the risk of having a child with genetic disease, we offer a thorough genetic test called GeneMatch that screens your genes for 400+ conditions and compares them with your donor’s genes to ensure that you are a healthy match. 

What is GeneMatch? 

Genetically inheritable diseases are caused by mutations in our genes that we pass on to our children. GeneMatch is a test determining whether your genes and those of your donor are a healthy match. The test determines whether you and your donor share mutations in the same gene that would result in your child inheriting a genetic disease. 

In short, by matching your genes we can determine if you and your donor carry mutations in the same genes and in this way determine if the future child is at risk of inheriting a disease.

GeneMatch screens for more than 400 genetic diseases and will give you an answer to ensure that you and your donor are a healthy match. 

Choose the donor(s) you would like to check your compatibility with 

When you have decided which of our donors you would like to proceed with for your fertility treatment, you can choose to add the GeneMatch test to check if you are a healthy match. The choice of this additional step in your donor search is entirely up to you. On the one hand, it may not feel necessary for you and you may choose to settle for how donor selection has been done up until now. On the other hand, performing a GeneMatch may give you an additional sense of security on your journey towards parenthood. The choice is yours.    

It is possible to purchase a GeneMatch test for just one donor or multiple donors* if you would like to check your match with more than one donor. The price for a single test is 1199 euro. 

*If the donor accepts additional genetic testing included in the GeneMatch test.

Three types of results
With the GeneMatch test, you will get an answer as either one of the three types of results below. 

1. You’re a good match

You do not carry mutations in the same genes as your donor. Your child is not at risk of inheriting any of the diseases covered by GeneMatch. If you’re a match, you will see this as “no incompatibility is observed” in your report.

2. You’re not a good match

You and your donor carry mutations in the same genes, meaning that your child is at risk of inheriting a genetic disease. If you’re not a match, you will see this as “incompatibility is observed” in your report.

We recommend that you choose a different donor and do a new GeneMatch.

3. You carry an X-linked disease

Your genes contain a mutation that could cause disease in your child if he is a boy.

How does it work? 

The process is quite simple. All you need to do is order the GeneMatch on each of the donors’ profile and we will send you a test kit. You will do a mouth swap to collect a sample of your saliva, which is to be sent to the test site. You will receive the result of your test 6 weeks after we have received your saliva sample. We will send you the test result in an email with the above information.  

We recommend that you that you purchase your preferred units and keep them in a storage until you receive your test result to ensure that your donor does not sell out in the meantime. 

More background information to understand how inheritance works

Inheritance explained 

Humans have approximately 30.000 functional genes. We have two copies of every gene. One inherited from our biological mother and one from our biological father. A genetic disorder can be either autosomal recessive, autosomal dominant or X-linked or Y-linked. 

Autosomal recessive: Both the mother and father’s genes play a part 

The focus of the GeneMatch test
When a genetic disorder is autosomal recessive it means that the affected gene is located on a chromosome different from the sex chromosomes, and that the disorder only is expressed if both versions of that particular gene are mutated. With just one version of the genes mutated, one is said to be carrier of the mutation/disorder (but not affected). Expectedly, every person is carrier of mutations. 

Being a carrier of a given mutation, there will be 50% risk that the mutation is passed on to children. This means that if both genetic parents are carrier of the same mutation, there will be a 50% risk that the child is carrier, 25% risk that the child will get both mutations and become sick, and 25% chance that the child will not get any of the mutations. Thus, the GeneMatch result “Not a Match” means that with this donor you will have 25% risk of getting a sick child. SellmerDiers recommends you find a different donor in such a case.

Autosomal dominant: When only one affected gene causes disease

When a genetic disorder is autosomal dominant, it means that the disorder will be expressed when only one of the two genes is affected. We do not focus on testing for autosomal dominant disorders since a such will be evident during the donor uptake process.

X-linked or Y-linked disorders: When the disease rises from the sex chromosomes

Disorders related to the sex chromosomes are called X-linked or Y-linked disorders. Since the Y-chromosome is very small compared to the X-chromosome, very few genetic disorders related to the sex chromosomes are Y-linked.

Females contain two X-chromosomes. Thus, a recessive X-linked disorder will not show in a female – only if both her X’es are affected by the same mutation. Males, however, containing both an X and a Y chromosome, will become sick if he carries an X-linked pathogenic mutation. This is because he does not have a healthy X to dominate the sick X. Therefore, for the same reason as for the autosomal dominant diseases, our donors are not genetically tested for X-linked disorders.

If a female is a carrier of an X-linked recessive disorder, her female offspring has a 50% risk of being a carrier of the same disorder (and 50% chance of not carrying). Her male offspring has the like risk of inheriting the disorder, however in contrast to the female offspring, the male offspring will become sick with the disorder if he has inherited the mutation.

When choosing our GeneMatch, 400+ genes most frequently related to autosomal recessive (and a few X-linked recessive) diseases will be matched to your chosen donor’s genetic profile. 

Our donor screening

From January 2021, donor recruitment includes screening for 20 of the most frequent and/or most severe recessive disorders. Potential donors are not included in our donor corps if they show to be carrier of one of these 20 disorders: 

Abnormal Karyotype, Cystic Fibrosis, Spinal Muscular Atrophy, Alpha-Thalassemia, Beta-Hemoglobinopathies, Non-Syndromic Hearing Loss (Connexin 26), Phenylketonuria, Ushers Syndrome, Wilson Disease, Pendreds Syndrome, Medium Chain Acyl-CoA Dehydrogenase Deficiency, Very Long-Chain Acyl-CoA Dehydrogenase Deficiency, Hereditary Fructose Intolerance, Glucose-6-Phosphate Dehydrogenase Deficiency, Congenital Adrenal Hyperplasia (21-hydroxylase-deficient), Smith-Lemli-Opitz Syndrome, Polycystic Kidney Disease, Congenital Disorder of Glycosylation, Alpha-1-Antitrypsin Deficiency, Hypothyroidism).

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